منابع مشابه
IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production
The most studied biological role of type III interferons (IFNs) has so far been their antiviral activity, but their role in autoimmune and inflammatory diseases remains largely unexplored. Here, we show that treatment with IFN-λ2/IL-28A completely halts and reverses the development of collagen-induced arthritis (CIA) and discover cellular and molecular mechanisms of IL-28A antiinflammatory func...
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Microglia mediate chronic neuroinflammation following central nervous system (CNS) disease or injury, and in doing so, damage the local brain environment by impairing recovery and contributing to disease processes. Microglia are critically dependent on signaling through the colony-stimulating factor 1 receptor (CSF1R) and can be eliminated via administration of CSF1R inhibitors. Resolving chron...
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Insulin-like growth factor-1 (IGF-1) is a growth factor with differentiating, anti-apoptotic and metabolic functions in the periphery, and anti-inflammatory properties in the nervous system. Mice that have mutations in the Igf1 gene, rendering the gene product inactive (Igf1(-/-)), present with age-related visual loss accompanied by structural alterations in the first synapses of the retinal pa...
متن کاملApoptosis, Cell Death and Inflammation
ceptors (e.g. members of the TNF superfamily such as TNFR1, CD95 or Toll-like receptors [4] ), or the intracellular sensors, nucleotide-binding and oligomerization domain (NOD)-like receptors [5, 6] , all of which can instigate inflammatory responses and modulate the cell’s survival/death balance. NOD-like receptors can assemble into large multiprotein complexes, termed inflammasomes, which can...
متن کاملApoptosis, cell death and inflammation.
ceptors (e.g. members of the TNF superfamily such as TNFR1, CD95 or Toll-like receptors [4] ), or the intracellular sensors, nucleotide-binding and oligomerization domain (NOD)-like receptors [5, 6] , all of which can instigate inflammatory responses and modulate the cell’s survival/death balance. NOD-like receptors can assemble into large multiprotein complexes, termed inflammasomes, which can...
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ژورنال
عنوان ژورنال: Science
سال: 2020
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.367.6475.261-c